B-hVWF mice
| Strain Name |
C57BL/6-Vwftm1(VWF)Bcgen/Bcgen
|
Common Name | B-hVWF mice |
| Background | C57BL/6 | Catalog number |
110907 |
| Aliases | VWF, F8VWF, VWD, von Willebrand factor | ||
模型验证
mRNA expression analysis
Protein expression analysis
Strain specific analysis of VWF gene expression in wild type (WT) mice and B-hVWF mice by RT-PCR. Mouse Vwf mRNA was detectable only in lung of WT mice (+/+). Human VWF mRNA was detectable only in homozygous B-hVWF mice (H/H) but not in WT mice (+/+).
Strain specific VWF expression analysis in wild type (WT) mice and B-hVWF mice by ELISA. Plasma were collected from WT mice (+/+) and homozygous B-hVWF mice (H/H), and analyzed by ELISA with VWF ELISA kit. Mouse VWF was detectable in WT mice (+/+) and homozygous B-hVWF mice (H/H) due to the cross-reactivity of antibodies. Human VWF was exclusively detectable in homozygous B-hVWF mice (H/H) but not WT mice (+/+) . Values are expressed as mean ± SEM. ND: not detectable.
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